The Research Center for Interaction with Cultural and Creative Industries of the University of Bologna aims to strengthen the regional production system and the economic development of the ICC sector by integrating research, digital and enabling technologies, creativity and culture. A series of interdisciplinary pilot projects have already been launched with the aim of developing new technological solutions to support innovation in the cultural and creative industries, with particular reference to the field of audiovisual activities (from music, to the performing and screen arts). and digital applications to culture; to explore transdisciplinary creative practices and associated creative and experimental methods, capable of generating new knowledge, new innovative production opportunities and business ideas to provide a multidisciplinary approach to the complex CCI sector. In this eco-system, the C.R.I.C.C. becomes a real hub of hybridization and contamination between Research & Development laboratories and local companies, in order to strengthen the open innovation model and the intelligent specialization of our region. Furthermore, the Research Center has signed agreements with the main Open Laboratories of the Emilia-Romagna region - a series of spaces for project collaboration between citizens, associations, companies, research centers, institutions - in order to activate a system of initiatives and events to be replicated in each Open Laboratory, to experiment with practices based on co-design activities.